Why LESS Sensitive Tests Might Be Better

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Published on 14 Jan 2021, 14:00
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This video written & produced in collaboration with Aatish Bhatia, aatishb.com

This video is about how cheap, fast, and LESS sensitive rapid antigen tests might be better for screening (& maybe surveillance) than PCR COVID tests due to the nature of contagiousness/infectiveness at various points on the viral load trajectory of symptomatic and asymptomatic COVID sars-COV-2 carriers.

REFERENCES

Thanks to Daniel Larremore for feedback on early versions of this video larremorelab.github.io

Rapid Antigen Testing:

COVID-19 testing: One size does not fit all. science.sciencemag.org/content...

Rethinking Covid-19 Test Sensitivity — A Strategy for Containment. nejm.org/doi/full/10.1056/NEJM...

Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening. advances.sciencemag.org/conten...

The effectiveness of population-wide, rapid antigen test based screening in reducing SARS-CoV-2 infection prevalence in Slovakia. (pre-print, not yet peer reviewed) medrxiv.org/content/10.1101/20...

Effective Testing and Screening for Covid-19. rockefellerfoundation.org/wp-c...

Brown University & Harvard University modeling of COVID-19 testing shortfall. globalepidemics.org/testing-ta...

Fast Coronavirus Tests are coming. media.nature.com/original/maga...

Open letter signed by epidemiologists and infectious disease experts supporting widespread & frequent rapid antigen testing for COVID-19: rapidtests.org/expert-letter

More information on various COVID-19 tests: chs.asu.edu/diagnostics-common...

Field performance and public health response using the BinaxNOW Rapid SARS-CoV-2 antigen detection assay during community-based testing. academic.oup.com/cid/advance-a...

Performance of an Antigen-Based Test for Asymptomatic and Symptomatic SARS-CoV-2 Testing at Two University Campuses. cdc.gov/mmwr/volumes/69/wr/mm6...

Asymptomatic Spread:

People without symptoms spread virus in more than half of cases, CDC model finds washingtonpost.com/science/202...

(More than half of all) SARS-CoV-2 Transmission From People Without COVID-19 Symptoms. jamanetwork.com/journals/jaman...

Three Quarters of People with SARS-CoV-2 Infection are Asymptomatic: Analysis of English Household Survey Data. ncbi.nlm.nih.gov/pmc/articles/...

Viral Load Curve:

SARS-CoV-2 viral dynamics in acute infections. (pre-print, not yet peer reviewed)
medrxiv.org/content/10.1101/20...


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